Meta-analysis of genome-wide **association studies:** no efficiency gain in using individual participant data. If no internal reference is available, we resort to an external reference panel such as the HapMap, 1000 Genomes, or ESP.16–18 It is desirable to use an internal or external reference Peters, Michael Preuss, Lynda M. It is preferable to use an internal than an external reference and to use a large reference panel.Our methods allow variants to be polymorphic in only some of the participating studies Check This Out

The summary results submitted to the consortium contain the effect estimates, the standard error estimates, and the two-sided p values of the association tests for individual SNPs. O’Connell, Yudi Pawitan, Eric E. Palmer, Aarno Palotie, John F. Let Y denote the trait of interest, which can be continuous or discrete, and let X denote a set of covariates (e.g., demographical variables and principal components for ancestry) plus the

König, Kati Kristiansson, Zoltán Kutalik, Claudia Lamina, Cecile Lecoeur, Guo Li, Massimo Mangino, Wendy L. Click here to see the non-JavaScript version of this site. Novell Documentation Novell Documentation is best viewed with JavaScript enabled. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

For the **linear model, γˆ=(∑i=1nXiXiT)−1∑i=1nYiXi and a(ϕˆ)=σˆ2=n−1∑i=1n(Yi−γˆTXi)2.** Berndt,2 Stefan Gustafsson,3 Andrea Ganna,3,4 Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Joel Hirschhorn,5,6,7 Kari E. This gene contains a few relatively common SNPs that are in modest LD. Am.

Groop, Talin Haritunian, Iris M. J. Let Zj denote the standard-normal statistic for testing the null hypothesis Hj:βj=0 under Equation 1 with βTG replaced by βjGj. navigate to this website Mol.

Note that X is correlated with S and may represent a principal component for ancestry. Lin D.Y., Tang Z.Z. For the logistic regression model, a(ϕ)=1, b(z)=log(1+ez), b′(z)=ez/(1+ez), and b″(z)=ez/(1+ez)2.For a study with n unrelated subjects, the data consist of (Yi,Gi,Xi) (i=1,…,n). Bioinformatics. 2008;24:140–142. [PubMed]23.

Under the null hypothesis of no association, (U˜1,…,U˜K)T is asymptotically K-variate normal with mean 0 and covariance matrix {V˜kl;k,l=1,…,K}, where V˜kl=ξkTV¯ξl. Collins, John M. We had access to the original data from one of the cohorts, the ARIC study,21 which contains 8,108 cohort members and 812 subjects with extreme height. For rare variants, the sejs may be unstable.

Fortunately version 5.5.3 (or later) of the GroupWise client provides a better way. (Check your version in Help About GroupWise) You will also need to have had Inter... [GroupWise] GroupWise Linux http://fileupster.com/groupwise-error/groupwise-error-601.html Croteau-Chonka, Felix R. For quantitative traits, both SV-I and SV-E are as powerful as MV. Medland, Evelin Mihailov, Lili Milani, Grant W.

Kiemeney, Diana Kuh, Markku Laakso, Terho Lehtimäki, Douglas F. Fourth, VT and variance-component tests are multivariate in nature, so the meta-analysis requires multivariate summary statistics (i.e., the components of the test statistic and their covariance matrix); combining the p values of This approach can accommodate any disease phenotype and any study design and produce all commonly used gene-level tests.The proposed approach not only greatly facilitates meta-analysis of sequencing studies but also provides this contact form Martin, Andres Metspalu, Andrew D.

The latter, together with the correlation matrix, would completely recover the multivariate statistics. J. For quantitative traits, both SV-I and SV-E with the score, LR, or Wald test are as accurate as MV.

McCarthy, Elizabeth K. Attwood, Anthony J. If we are interested in K burden scores with vectors of weights ξ1,…,ξK, then we calculate U˜k=ξkTU¯(k=1,…,K). Hall, Per Hall, Anna-Liisa Hartikainen, Caroline Hayward, Nancy L.

Psaty, Lu Qi, Rainer Rauramaa, Paul M. For quantitative traits, the results based on the Wald and LR tests are virtually identical to those of the score test (data not shown). Am. navigate here Lango Allen H., Estrada K., Lettre G., Berndt S.I., Weedon M.N., Rivadeneira F., Willer C.J., Jackson A.U., Vedantam S., Raychaudhuri S.

If an internal reference study is available, we may set wj={(n/n∗)Vjj∗}1/2, where n∗ and Vjj∗ are the values of n and Vjj for the reference study, the reason being that Vjj Levinson, Nicholas G. Hum. Magnusson, Paolo Manunta, Diana Marek, Winfried März, Irene Mateo Leach, Barbara McKnight, Sarah E.

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